Senolytic Activator- Anti-Aging, Longevity, 36 Vege Caps

Life Extension SKU: LX23012
Senolytic Activator- Anti-Aging, Longevity, 36 Vege Caps
Senolytic Activator- Anti-Aging, Longevity, 36 Vege Caps

Senolytic Activator- Anti-Aging, Longevity, 36 Vege Caps

Life Extension SKU: LX23012
Regular price $24.98 USD Sale price $19.99 USD Save 20%
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    Product Details

    Combat cellular senescence

    Senolytic Activator® combines black tea theaflavins, the plant-derived flavonoid apigenin, and ultra-absorbable forms of the bio-flavonoids quercetin and fisetin to help manage senescent cell burden and promote systemic rejuvenation.
    Gluten free Non-GMO Vegetarian

    Product Details

    Cellular senescence is a natural part of the aging process in which cells no longer function optimally. Senescent cells can accumulate over time, affecting the day-to-day function of the healthy cells around them.

    Senolytic compounds selectively target senescent cells.1 New research indicates that black tea theaflavins and quercetin target specific biological pathways, making it easier for the body to manage senescent cells.2-4

    Theaflavins reduce senescent cell burden

    Theaflavins are compounds derived from Camellia sinensis (tea plant). These compounds have widespread health benefits, supporting healthy cell division and healthy inflammatory response.5,6

    New research indicates that theaflavins may be especially helpful for reducing senescent cell burden. In pre-clinical models, theaflavins helped powerfully inhibit the accumulation of particular cell senescence biomarkers.2

    Quercetin promotes cellular health and more

    Quercetin supports endothelial and cardiovascular health, promotes healthy immune function and more.7,8 The value of quercetin has been recognized for some time. But its potential to meaningfully impact whole body rejuvenation is just starting to be uncovered through its senolytic activity. The discovery that quercetin is a senolytic compound has drawn significant attention to this innovative approach to combat aging.4

    Better absorption than standard types of quercetin

    Standard quercetin is hard to absorb. But this formulation features our new quercetin phytosome, a phospholipid sphere that encases the quercetin, aiding in its absorption and making it up to 50 times more bioavailable.

    Easy-to-absorb fisetin to boost longevity at the cellular level

    Fisetin is terrific for whole-body health. It’s a powerful senolytic compound, meaning it actively target senescent cells, the ones that no longer function optimally. Fisetin helps encourage the body’s natural pathways for clearing senescent cells, which allows healthy cells to flourish.9

    Another important aspect of cellular longevity is sirtuin function. Sirtuin proteins keep your cells performing at their best—but sirtuin activity declines with age.10 Fisetin has been shown in preclinical studies to encourage youthful, healthy sirtuin function.11-15

    But during digestion, much of fisetin is rapidly converted into other compounds by a process called conjugation. That’s why we protected fisetin by combining it with galactomannans, a type of fiber derived from fenugreek seed. Doing so makes it up to 25 times more readily available than standard fisetin.16 That means it circulates in your system longer and your body has more time to access fisetin’s many health benefits.


    Life Extension has identified apigenin, a natural flavonoid, as a powerful addition to our Senolytic Activator® formula. Quercetin and theaflavins from black tea target senescent cells, but not all of them.

    The remaining senescent cells create compounds known collectively as Senescence Associated Secretory Phenotype, or SASP.17 Apigenin helps inhibit remaining senescent cells from making SASP to support cellular and tissue health—a critical aspect of healthy aging.18

    Convenient, once-weekly formula

    For those who aren’t keen on adding another supplement to their regimen, here’s good news: Senolytic research indicates that intermittent dosing in pre-clinical studies is effective at supporting healthspan.4 So, Senolytic Activator® instructions call for taking just three vegetarian capsules, once a week.
    Manage senescent cells, promote healthy cellular function and support overall longevity with Senolytic Activator®.


    Dosage and Use

    Take three (3) capsules once weekly, or as recommended by a healthcare practitioner.

    Suggested Use

    Take one capsule once or twice daily with or without food, or as recommended by a healthcare practitioner.

    Supplement Facts

    Serving Size: 3 vegetarian capsule
    Servings per Container: 12

     Amount Per Serving% Daily Value
    Bio-Fisetin Proprietary Blend
    Providing 18% fisetin (56 mg) [from wax tree extract (stem)], 35% galactomannans (109 mg) [from fenugreek (seed)]
    312 mg**
    Theaflavins [from decaffeinated black tea extract (leaf)]275 mg**
    Bio-Quercetin phytosome 25 mg quercetin [from Japanese sophora concentrate (flower bud)], phosphatidylcholine complex [from sunflower])74 mg**
    Apigenin50 mg**
    ** Daily Value not established.

    Other ingredients: vegetable cellulose (capsule), sunflower lecithin, microcrystalline cellulose, silica, vegetable stearate.


    • Do not purchase if outer seal is broken or damaged.
    • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

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